| Summary: | We evaluated the antimicrobial activity of Aspilia latissima - an
abundant plant from the Brazilian Pantanal region - against Candida albicans,
Candida parapsilosis, Candida krusei, Candida tropicalis, Pseudomonas aeruginosa,
Enterococcus faecalis, Escherichia coli and Staphylococcus
aureus. The crude extracts and fractions showed activity in all tested
microorganisms. The chloroform fraction of the leaves and roots showed the most
antimicrobial activity against S. aureus, with an MIC of 500 μg/mL.
This fraction was submitted to bioautographic assays to characterize the activity of
the compounds. Two bands from the leaves (L-A and L-B) and three bands from the roots
(R-C, R-D and R-E) were bioactive. Within the root-derived bands, the terpene
derivatives stigmasterol, kaurenoic acid and kaura-9(11), 16-dien-18-oic acid were
identified. Antibiotic activity of A. latissima is reported for the
first time.
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