Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists

Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists

Bile acids are the endogenous modulators of the nuclear receptor FXR and the membrane receptor GPBAR1. FXR represents a promising pharmacological target for the treatment of cholestatic liver disorders. Currently available semisynthetic bile acid derivatives cover the same chemical space of bile aci...

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Bibliographic Details
Main Authors: Sepe, Valentina, Festa, Carmen, Renga, Barbara, Carino, Adriana, Cipriani, Sabrina, Finamore, Claudia, Masullo, Dario, del Gaudio, Federica, Monti, Maria Chiara, Fiorucci, Stefano, Zampella, Angela
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704022/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704022/

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