Membrane Binding and Modulation of the PDZ Domain of PICK1

Scaffolding proteins serve to assemble protein complexes in dynamic processes by means of specific protein-protein and protein-lipid binding domains. Many of these domains bind either proteins or lipids exclusively; however, it has become increasingly evident that certain domains are capable of bind...

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Main Authors:	Erlendsson, Simon, Madsen, Kenneth Lindegaard
Format:	Online
Language:	English
Published:	MDPI 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704001/

id	pubmed-4704001
recordtype	oai_dc
spelling	pubmed-47040012016-01-21 Membrane Binding and Modulation of the PDZ Domain of PICK1 Erlendsson, Simon Madsen, Kenneth Lindegaard Review Scaffolding proteins serve to assemble protein complexes in dynamic processes by means of specific protein-protein and protein-lipid binding domains. Many of these domains bind either proteins or lipids exclusively; however, it has become increasingly evident that certain domains are capable of binding both. Especially, many PDZ domains, which are highly abundant protein-protein binding domains, bind lipids and membranes. Here we provide an overview of recent large-scale studies trying to generalize and rationalize the binding patterns as well as specificity of PDZ domains towards membrane lipids. Moreover, we review how these PDZ-membrane interactions are regulated in the case of the synaptic scaffolding protein PICK1 and how this might affect cellular localization and function. MDPI 2015-10-16 /pmc/articles/PMC4704001/ /pubmed/26501328 http://dx.doi.org/10.3390/membranes5040597 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Erlendsson, Simon Madsen, Kenneth Lindegaard
spellingShingle	Erlendsson, Simon Madsen, Kenneth Lindegaard Membrane Binding and Modulation of the PDZ Domain of PICK1
author_facet	Erlendsson, Simon Madsen, Kenneth Lindegaard
author_sort	Erlendsson, Simon
title	Membrane Binding and Modulation of the PDZ Domain of PICK1
title_short	Membrane Binding and Modulation of the PDZ Domain of PICK1
title_full	Membrane Binding and Modulation of the PDZ Domain of PICK1
title_fullStr	Membrane Binding and Modulation of the PDZ Domain of PICK1
title_full_unstemmed	Membrane Binding and Modulation of the PDZ Domain of PICK1
title_sort	membrane binding and modulation of the pdz domain of pick1
description	Scaffolding proteins serve to assemble protein complexes in dynamic processes by means of specific protein-protein and protein-lipid binding domains. Many of these domains bind either proteins or lipids exclusively; however, it has become increasingly evident that certain domains are capable of binding both. Especially, many PDZ domains, which are highly abundant protein-protein binding domains, bind lipids and membranes. Here we provide an overview of recent large-scale studies trying to generalize and rationalize the binding patterns as well as specificity of PDZ domains towards membrane lipids. Moreover, we review how these PDZ-membrane interactions are regulated in the case of the synaptic scaffolding protein PICK1 and how this might affect cellular localization and function.
publisher	MDPI
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704001/
_version_	1613520882401017856

Membrane Binding and Modulation of the PDZ Domain of PICK1

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