Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development

Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development

Abnormal activation of SETBP1 through overexpression or missense mutations is highly recurrent in various myeloid malignancies; however, it is unclear whether such activation alone is able to induce leukemia development. Here we show that Setbp1 overexpression in mouse bone marrow progenitors throug...

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Bibliographic Details
Main Authors: Vishwakarma, Bandana A., Nguyen, Nhu, Makishima, Hideki, Hosono, Naoko, Gudmundsson, Kristbjorn O., Negi, Vijay, Oakley, Kevin, Han, Yufen, Przychodzen, Bartlomiej, Maciejewski, Jaroslaw P., Du, Yang
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703539/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703539/

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