Dual Inhibition of CDK4/Rb and PI3K/AKT/mTOR Pathways by ON123300 Induces Synthetic Lethality in Mantle Cell Lymphomas

Dual Inhibition of CDK4/Rb and PI3K/AKT/mTOR Pathways by ON123300 Induces Synthetic Lethality in Mantle Cell Lymphomas

This study describes the characterization of a novel kinase inhibitor, ON123300, which inhibits CDK4/6 and PI3K-δ and exhibits potent activity against mantle cell lymphomas (MCLs) both in vitro and in vivo. We examined the effects of PD0332991 and ON 123300 on cell cycle progression, modulation of t...

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Bibliographic Details
Main Authors: Divakar, Saikrishna A., Reddy, M.V. Ramana, Cosenza, Stephen C., Baker, Stacey J., Perumal, Deepak, Antonelli, Anthony C., Brody, Joshua, Akula, Balaiah, Parekh, Samir, Reddy, E. Premkumar
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703501/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703501/

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