Modeling the evolution space of breakage fusion bridge cycles with a stochastic folding process
Breakage–fusion–bridge cycles in cancer arise when a broken segment of DNA is duplicated and an end from each copy joined together. This structure then ‘unfolds’ into a new piece of palindromic DNA. This is one mechanism responsible for the localised amplicons observed in cancer genome data. Here we...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Springer Berlin Heidelberg
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702116/ |