Escherichia coli Heat-Stable Enterotoxin Mediates Na+/H+ Exchanger 4 Inhibition Involving cAMP in T84 Human Intestinal Epithelial Cells

Escherichia coli Heat-Stable Enterotoxin Mediates Na+/H+ Exchanger 4 Inhibition Involving cAMP in T84 Human Intestinal Epithelial Cells

The enterotoxigenic Escherichia coli strains lead to diarrhoea in humans due to heat-labile and heat-stable (STa) enterotoxins. STa increases Cl-release in intestinal cells, including the human colonic carcinoma T84 cell line, involving increased cGMP and membrane alkalization due to reduced Na+/H+...

Full description

Bibliographic Details
Main Authors: Beltrán, Ana R., Carraro-Lacroix, Luciene R., Bezerra, Camila N. A., Cornejo, Marcelo, Norambuena, Katrina, Toledo, Fernando, Araos, Joaquín, Pardo, Fabián, Leiva, Andrea, Sanhueza, Carlos, Malnic, Gerhard, Sobrevia, Luis, Ramírez, Marco A.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699896/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699896/

Similar Items