siRNA screen identifies QPCT as a druggable target for Huntington’s disease

siRNA screen identifies QPCT as a druggable target for Huntington’s disease

Huntington’s disease (HD) is a currently incurable neurodegenerative condition caused by an abnormally expanded polyglutamine tract in huntingtin (HTT). We identified novel modifiers of mutant HTT toxicity by performing a large-scale “druggable genome” siRNA screen in human cultured cells, followed...

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Bibliographic Details
Main Authors: Jimenez-Sanchez, Maria, Lam, Wun, Hannus, Michael, Sönnichsen, Birte, Imarisio, Sara, Fleming, Angeleen, Tarditi, Alessia, Menzies, Fiona, Dami, Teresa Ed, Xu, Catherine, Gonzalez-Couto, Eduardo, Lazzeroni, Giulia, Heitz, Freddy, Diamanti, Daniela, Massai, Luisa, Satagopam, Venkata P., Marconi, Guido, Caramelli, Chiara, Nencini, Arianna, Andreini, Matteo, Sardone, Gian Luca, Caradonna, Nicola P., Porcari, Valentina, Scali, Carla, Schneider, Reinhard, Pollio, Giuseppe, O’Kane, Cahir J., Caricasole, Andrea, Rubinsztein, David C.
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696152/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696152/

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