Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation

Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation

Cholangiocarcinoma is an aggressive, strongly chemoresistant liver malignancy. Leukemia inhibitory factor (LIF), an IL-6 family cytokine, promotes progression of various carcinomas. To investigate the role of LIF in cholangiocarcinoma, we evaluated the expression of LIF and its receptor (LIFR) in hu...

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Bibliographic Details
Main Authors: Morton, Stuart Duncan, Cadamuro, Massimiliano, Brivio, Simone, Vismara, Marta, Stecca, Tommaso, Massani, Marco, Bassi, Nicolò, Furlanetto, Alberto, Joplin, Ruth Elizabeth, Floreani, Annarosa, Fabris, Luca, Strazzabosco, Mario
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694885/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694885/

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