ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer

ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer

Activation of cancer stem cell signaling is central to acquired resistance to therapy in esophageal cancer (EC). ABT-263, a potent Bcl-2 family inhibitor, is active against many tumor types. However, effect of ABT-263 on EC cells and their resistant counterparts are unknown. Here we report that ABT-...

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Bibliographic Details
Main Authors: Chen, Qiongrong, Song, Shumei, Wei, Shaozhong, Liu, Bin, Honjo, Soichiro, Scott, Ailing, Jin, Jiankang, Ma, Lang, Zhu, Haitao, Skinner, Heath D., Johnson, Randy L., Ajani, Jaffer A.
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694873/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694873/

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