Targeting endosialin/CD248 through antibody-mediated internalization results in impaired pericyte maturation and dysfunctional tumor microvasculature

Targeting endosialin/CD248 through antibody-mediated internalization results in impaired pericyte maturation and dysfunctional tumor microvasculature

Over-expression of endosialin/CD248 (herein referred to as CD248) has been associated with increased tumor microvasculature in various tissue origins which makes it an attractive anti-angiogenic target. In an effort to target CD248, we have generated a human CD248 knock-in mouse line and MORAb-004,...

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Bibliographic Details
Main Authors: Rybinski, Katherine, Imtiyaz, Hongxia Z., Mittica, Barrie, Drozdowski, Brian, Fulmer, James, Furuuchi, Keiji, Fernando, Shawn, Henry, Marianne, Chao, Qimin, Kline, Brad, Albone, Earl, Wustner, Jason, Lin, JianMin, Nicolaides, Nicholas C., Grasso, Luigi, Zhou, Yuhong
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694842/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694842/

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