JAML mediates monocyte and CD8 T cell migration across the brain endothelium

JAML mediates monocyte and CD8 T cell migration across the brain endothelium

Leukocyte transmigration into the central nervous system promotes multiple sclerosis pathogenesis, yet ambiguity remains regarding the mechanisms controlling the migration of distinct immune cell subsets. Using in vitro, ex vivo and postmortem human materials, we identified a significant upregulatio...

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Main Authors: Alvarez, Jorge Iván, Kébir, Hania, Cheslow, Lara, Chabarati, Marc, Larochelle, Catherine, Prat, Alexandre
Format: Online
Language:English
Published: John Wiley and Sons Inc. 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693623/
id pubmed-4693623
recordtype oai_dc
spelling pubmed-46936232016-01-05 JAML mediates monocyte and CD8 T cell migration across the brain endothelium Alvarez, Jorge Iván Kébir, Hania Cheslow, Lara Chabarati, Marc Larochelle, Catherine Prat, Alexandre Brief Communications Leukocyte transmigration into the central nervous system promotes multiple sclerosis pathogenesis, yet ambiguity remains regarding the mechanisms controlling the migration of distinct immune cell subsets. Using in vitro, ex vivo and postmortem human materials, we identified a significant upregulation of junctional adhesion molecule‐like expression at the blood–brain barrier, monocytes, and CD8 T cells of multiple sclerosis patients. We also detected junctional adhesion molecule‐like+ trans‐migratory cups when monocytes/CD8 T cells adhered to the blood–brain barrier, however, their migratory capacity was significantly compromised when junctional adhesion molecule‐like was blocked. These findings highlight a novel role for junctional adhesion molecule‐like in leukocyte transmigration and its potential as a promising therapeutic target. John Wiley and Sons Inc. 2015-09-29 /pmc/articles/PMC4693623/ /pubmed/26734656 http://dx.doi.org/10.1002/acn3.255 Text en © 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Alvarez, Jorge Iván
Kébir, Hania
Cheslow, Lara
Chabarati, Marc
Larochelle, Catherine
Prat, Alexandre
spellingShingle Alvarez, Jorge Iván
Kébir, Hania
Cheslow, Lara
Chabarati, Marc
Larochelle, Catherine
Prat, Alexandre
JAML mediates monocyte and CD8 T cell migration across the brain endothelium
author_facet Alvarez, Jorge Iván
Kébir, Hania
Cheslow, Lara
Chabarati, Marc
Larochelle, Catherine
Prat, Alexandre
author_sort Alvarez, Jorge Iván
title JAML mediates monocyte and CD8 T cell migration across the brain endothelium
title_short JAML mediates monocyte and CD8 T cell migration across the brain endothelium
title_full JAML mediates monocyte and CD8 T cell migration across the brain endothelium
title_fullStr JAML mediates monocyte and CD8 T cell migration across the brain endothelium
title_full_unstemmed JAML mediates monocyte and CD8 T cell migration across the brain endothelium
title_sort jaml mediates monocyte and cd8 t cell migration across the brain endothelium
description Leukocyte transmigration into the central nervous system promotes multiple sclerosis pathogenesis, yet ambiguity remains regarding the mechanisms controlling the migration of distinct immune cell subsets. Using in vitro, ex vivo and postmortem human materials, we identified a significant upregulation of junctional adhesion molecule‐like expression at the blood–brain barrier, monocytes, and CD8 T cells of multiple sclerosis patients. We also detected junctional adhesion molecule‐like+ trans‐migratory cups when monocytes/CD8 T cells adhered to the blood–brain barrier, however, their migratory capacity was significantly compromised when junctional adhesion molecule‐like was blocked. These findings highlight a novel role for junctional adhesion molecule‐like in leukocyte transmigration and its potential as a promising therapeutic target.
publisher John Wiley and Sons Inc.
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693623/
_version_ 1613517464436473856

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