Concord Grape Juice Polyphenols and Cardiovascular Risk Factors: Dose-Response Relationships

Concord Grape Juice Polyphenols and Cardiovascular Risk Factors: Dose-Response Relationships

Pure fruit juices provide nutritional value with evidence suggesting some of their benefits on biomarkers of cardiovascular disease risk may be derived from their constituent polyphenols, particularly flavonoids. However, few data from clinical trials are available on the dose-response relationship...

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Main Authors: Blumberg, Jeffrey B., Vita, Joseph A., Chen, C. -Y. Oliver
Format: Online
Language:English
Published: MDPI 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690071/
id pubmed-4690071
recordtype oai_dc
spelling pubmed-46900712015-12-30 Concord Grape Juice Polyphenols and Cardiovascular Risk Factors: Dose-Response Relationships Blumberg, Jeffrey B. Vita, Joseph A. Chen, C. -Y. Oliver Article Pure fruit juices provide nutritional value with evidence suggesting some of their benefits on biomarkers of cardiovascular disease risk may be derived from their constituent polyphenols, particularly flavonoids. However, few data from clinical trials are available on the dose-response relationship of fruit juice flavonoids to these outcomes. Utilizing the results of clinical trials testing single doses, we have analyzed data from studies of 100% Concord grape juice by placing its flavonoid content in the context of results from randomized clinical trials of other polyphenol-rich foods and beverages describing the same outcomes but covering a broader range of intake. We selected established biomarkers determined by similar methods for measuring flow-mediated vasodilation (FMD), blood pressure, platelet aggregation, and the resistance of low density lipoprotein cholesterol (LDL) to oxidation. Despite differences among the clinical trials in the treatment, subjects, and duration, correlations were observed between the dose and FMD. Inverse dose-response relationships, albeit with lower correlation coefficients, were also noted for the other outcomes. These results suggest a clear relationship between consumption of even modest serving sizes of Concord grape juice, flavonoid intake, and effects on risk factors for cardiovascular disease. This approach to dose-response relationships may prove useful for testing other individual foods and beverages. MDPI 2015-12-02 /pmc/articles/PMC4690071/ /pubmed/26633488 http://dx.doi.org/10.3390/nu7125519 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Blumberg, Jeffrey B.
Vita, Joseph A.
Chen, C. -Y. Oliver
spellingShingle Blumberg, Jeffrey B.
Vita, Joseph A.
Chen, C. -Y. Oliver
Concord Grape Juice Polyphenols and Cardiovascular Risk Factors: Dose-Response Relationships
author_facet Blumberg, Jeffrey B.
Vita, Joseph A.
Chen, C. -Y. Oliver
author_sort Blumberg, Jeffrey B.
title Concord Grape Juice Polyphenols and Cardiovascular Risk Factors: Dose-Response Relationships
title_short Concord Grape Juice Polyphenols and Cardiovascular Risk Factors: Dose-Response Relationships
title_full Concord Grape Juice Polyphenols and Cardiovascular Risk Factors: Dose-Response Relationships
title_fullStr Concord Grape Juice Polyphenols and Cardiovascular Risk Factors: Dose-Response Relationships
title_full_unstemmed Concord Grape Juice Polyphenols and Cardiovascular Risk Factors: Dose-Response Relationships
title_sort concord grape juice polyphenols and cardiovascular risk factors: dose-response relationships
description Pure fruit juices provide nutritional value with evidence suggesting some of their benefits on biomarkers of cardiovascular disease risk may be derived from their constituent polyphenols, particularly flavonoids. However, few data from clinical trials are available on the dose-response relationship of fruit juice flavonoids to these outcomes. Utilizing the results of clinical trials testing single doses, we have analyzed data from studies of 100% Concord grape juice by placing its flavonoid content in the context of results from randomized clinical trials of other polyphenol-rich foods and beverages describing the same outcomes but covering a broader range of intake. We selected established biomarkers determined by similar methods for measuring flow-mediated vasodilation (FMD), blood pressure, platelet aggregation, and the resistance of low density lipoprotein cholesterol (LDL) to oxidation. Despite differences among the clinical trials in the treatment, subjects, and duration, correlations were observed between the dose and FMD. Inverse dose-response relationships, albeit with lower correlation coefficients, were also noted for the other outcomes. These results suggest a clear relationship between consumption of even modest serving sizes of Concord grape juice, flavonoid intake, and effects on risk factors for cardiovascular disease. This approach to dose-response relationships may prove useful for testing other individual foods and beverages.
publisher MDPI
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690071/
_version_ 1613516403244007424

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