Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction

Viruses impose diverse and dynamic challenges on host defenses. Diversifying selection of codons and gene copy number variation are two hallmarks of genetic innovation in antiviral genes engaged in host-virus genetic conflicts. The myxovirus resistance (Mx) genes encode interferon-inducible GTPases...

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Bibliographic Details
Main Authors: Mitchell, Patrick S., Young, Janet M., Emerman, Michael, Malik, Harmit S.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687636/