Profound parental bias associated with chromosome 14 acquired uniparental disomy indicates targeting of an imprinted locus

Profound parental bias associated with chromosome 14 acquired uniparental disomy indicates targeting of an imprinted locus

Acquired uniparental disomy (aUPD) is a common finding in myeloid malignancies and typically acts to convert a somatically acquired heterozygous mutation to homozygosity. We sought to identify the target of chromosome 14 aUPD (aUPD14), a recurrent abnormality in myeloid neoplasms and population coho...

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Bibliographic Details
Main Authors: Chase, A, Leung, W, Tapper, W, Jones, A V, Knoops, L, Rasi, C, Forsberg, L A, Guglielmelli, P, Zoi, K, Hall, V, Chiecchio, L, Eder-Azanza, L, Bryant, C, Lannfelt, L, Docherty, L, White, H E, Score, J, Mackay, D J G, Vannucchi, A M, Dumanski, J P, Cross, N C P
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687469/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687469/

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