Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation

Two distinct pathways deliver secretory proteins to the Sec61 protein translocase in the endoplasmic reticulum membrane. The canonical pathway requires the signal recognition particle (SRP) and its cognate receptor (SR), and targets ribosome-associated proteins to the Sec translocase. The SRP-indepe...

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Bibliographic Details
Main Authors: Jadhav, Bhalchandra, McKenna, Michael, Johnson, Nicholas, High, Stephen, Sinning, Irmgard, Pool, Martin R.
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686813/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686813/

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