Controlled Human Malaria Infection (CHMI) differentially affects cell-mediated and antibody responses to CSP and AMA1 induced by adenovirus vaccines with and without DNA-priming

Controlled Human Malaria Infection (CHMI) differentially affects cell-mediated and antibody responses to CSP and AMA1 induced by adenovirus vaccines with and without DNA-priming

We have previously shown that a DNA-prime followed by an adenovirus-5 boost vaccine containing CSP and AMA1 (DNA/Ad) successfully protected 4 of 15 subjects to controlled human malaria infection (CHMI). However, the adenovirus-5 vaccine alone (AdCA) failed to induce protection despite eliciting cell...

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Bibliographic Details
Main Authors: Sedegah, Martha, Hollingdale, Michael R, Farooq, Fouzia, Ganeshan, Harini, Belmonte, Maria, Huang, Jun, Abot, Esteban, Limbach, Keith, Chuang, Ilin, Tamminga, Cindy, Epstein, Judith E, Villasante, Eileen
Format: Online
Language:English
Published: Taylor & Francis 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685686/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685686/

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