Topography of acute stroke in a sample of 439 right brain damaged patients
Knowledge of the typical lesion topography and volumetry is important for clinical stroke diagnosis as well as for anatomo-behavioral lesion mapping analyses. Here we used modern lesion analysis techniques to examine the naturally occurring lesion patterns caused by ischemic and by hemorrhagic infar...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Elsevier
2015
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683427/ |
| id |
pubmed-4683427 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-46834272016-01-12 Topography of acute stroke in a sample of 439 right brain damaged patients Sperber, Christoph Karnath, Hans-Otto Regular Article Knowledge of the typical lesion topography and volumetry is important for clinical stroke diagnosis as well as for anatomo-behavioral lesion mapping analyses. Here we used modern lesion analysis techniques to examine the naturally occurring lesion patterns caused by ischemic and by hemorrhagic infarcts in a large, representative acute stroke patient sample. Acute MR and CT imaging of 439 consecutively admitted right-hemispheric stroke patients from a well-defined catchment area suffering from ischemia (n = 367) or hemorrhage (n = 72) were normalized and mapped in reference to stereotaxic anatomical atlases. For ischemic infarcts, highest frequencies of stroke were observed in the insula, putamen, operculum and superior temporal cortex, as well as the inferior and superior occipito-frontal fascicles, superior longitudinal fascicle, uncinate fascicle, and the acoustic radiation. The maximum overlay of hemorrhages was located more posteriorly and more medially, involving posterior areas of the insula, Heschl's gyrus, and putamen. Lesion size was largest in frontal and anterior areas and lowest in subcortical and posterior areas. The large and unbiased sample of stroke patients used in the present study accumulated the different sub-patterns to identify the global topographic and volumetric pattern of right hemisphere stroke in humans. Elsevier 2015-11-17 /pmc/articles/PMC4683427/ /pubmed/26759787 http://dx.doi.org/10.1016/j.nicl.2015.11.012 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Sperber, Christoph Karnath, Hans-Otto |
| spellingShingle |
Sperber, Christoph Karnath, Hans-Otto Topography of acute stroke in a sample of 439 right brain damaged patients |
| author_facet |
Sperber, Christoph Karnath, Hans-Otto |
| author_sort |
Sperber, Christoph |
| title |
Topography of acute stroke in a sample of 439 right brain damaged patients |
| title_short |
Topography of acute stroke in a sample of 439 right brain damaged patients |
| title_full |
Topography of acute stroke in a sample of 439 right brain damaged patients |
| title_fullStr |
Topography of acute stroke in a sample of 439 right brain damaged patients |
| title_full_unstemmed |
Topography of acute stroke in a sample of 439 right brain damaged patients |
| title_sort |
topography of acute stroke in a sample of 439 right brain damaged patients |
| description |
Knowledge of the typical lesion topography and volumetry is important for clinical stroke diagnosis as well as for anatomo-behavioral lesion mapping analyses. Here we used modern lesion analysis techniques to examine the naturally occurring lesion patterns caused by ischemic and by hemorrhagic infarcts in a large, representative acute stroke patient sample. Acute MR and CT imaging of 439 consecutively admitted right-hemispheric stroke patients from a well-defined catchment area suffering from ischemia (n = 367) or hemorrhage (n = 72) were normalized and mapped in reference to stereotaxic anatomical atlases. For ischemic infarcts, highest frequencies of stroke were observed in the insula, putamen, operculum and superior temporal cortex, as well as the inferior and superior occipito-frontal fascicles, superior longitudinal fascicle, uncinate fascicle, and the acoustic radiation. The maximum overlay of hemorrhages was located more posteriorly and more medially, involving posterior areas of the insula, Heschl's gyrus, and putamen. Lesion size was largest in frontal and anterior areas and lowest in subcortical and posterior areas. The large and unbiased sample of stroke patients used in the present study accumulated the different sub-patterns to identify the global topographic and volumetric pattern of right hemisphere stroke in humans. |
| publisher |
Elsevier |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683427/ |
| _version_ |
1613514140669706240 |