Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled*

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled*

Frizzled is the earliest discovered glycosylated Wnt protein receptor and is critical for the initiation of Wnt signaling. Antagonizing Frizzled is effective in inhibiting the growth of multiple tumor types. The extracellular N terminus of Frizzled contains a conserved cysteine-rich domain that dire...

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Bibliographic Details
Main Authors: Lee, Ho-Jin, Bao, Ju, Miller, Ami, Zhang, Chi, Wu, Jibo, Baday, Yiressy C., Guibao, Cristina, Li, Lin, Wu, Dianqing, Zheng, Jie J.
Format: Online
Language:English
Published: American Society for Biochemistry and Molecular Biology 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683279/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683279/

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