Differential Regulation of NF-κB-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins

Differential Regulation of NF-κB-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins

NF-κB is essential for effective transcription of primate lentiviral genomes and also activates antiviral host genes. Here, we show that the early protein Nef of most primate lentiviruses enhances NF-κB activation. In contrast, the late protein Vpu of HIV-1 and its simian precursors inhibits activat...

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Bibliographic Details
Main Authors: Sauter, Daniel, Hotter, Dominik, Van Driessche, Benoît, Stürzel, Christina M., Kluge, Silvia F., Wildum, Steffen, Yu, Hangxing, Baumann, Bernd, Wirth, Thomas, Plantier, Jean-Christophe, Leoz, Marie, Hahn, Beatrice H., Van Lint, Carine, Kirchhoff, Frank
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682570/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682570/

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