Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits

In the development of addiction, drug seeking becomes habitual and controlled by drug-associated cues, and the neural locus of control over behaviour shifts from the ventral to the dorsolateral striatum. The neural mechanisms underlying this functional transition from recreational drug use to drug-s...

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Main Authors:	Murray, Jennifer E., Belin-Rauscent, Aude, Simon, Marine, Giuliano, Chiara, Benoit-Marand, Marianne, Everitt, Barry J., Belin, David
Format:	Online
Language:	English
Published:	Nature Publishing Group 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682035/

id	pubmed-4682035
recordtype	oai_dc
spelling	pubmed-46820352015-12-29 Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits Murray, Jennifer E. Belin-Rauscent, Aude Simon, Marine Giuliano, Chiara Benoit-Marand, Marianne Everitt, Barry J. Belin, David Article In the development of addiction, drug seeking becomes habitual and controlled by drug-associated cues, and the neural locus of control over behaviour shifts from the ventral to the dorsolateral striatum. The neural mechanisms underlying this functional transition from recreational drug use to drug-seeking habits are unknown. Here we combined functional disconnections and electrophysiological recordings of the amygdalo-striatal networks in rats trained to seek cocaine to demonstrate that functional shifts within the striatum are driven by transitions from the basolateral (BLA) to the central (CeN) amygdala. Thus, while the recruitment of dorsolateral striatum dopamine-dependent control over cocaine seeking is triggered by the BLA, its long-term maintenance depends instead on the CeN. These data demonstrate that limbic cortical areas both tune the function of cognitive territories of the striatum and thereby underpin maladaptive cocaine-seeking habits. Nature Publishing Group 2015-12-14 /pmc/articles/PMC4682035/ /pubmed/26657320 http://dx.doi.org/10.1038/ncomms10088 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Murray, Jennifer E. Belin-Rauscent, Aude Simon, Marine Giuliano, Chiara Benoit-Marand, Marianne Everitt, Barry J. Belin, David
spellingShingle	Murray, Jennifer E. Belin-Rauscent, Aude Simon, Marine Giuliano, Chiara Benoit-Marand, Marianne Everitt, Barry J. Belin, David Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits
author_facet	Murray, Jennifer E. Belin-Rauscent, Aude Simon, Marine Giuliano, Chiara Benoit-Marand, Marianne Everitt, Barry J. Belin, David
author_sort	Murray, Jennifer E.
title	Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits
title_short	Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits
title_full	Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits
title_fullStr	Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits
title_full_unstemmed	Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits
title_sort	basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits
description	In the development of addiction, drug seeking becomes habitual and controlled by drug-associated cues, and the neural locus of control over behaviour shifts from the ventral to the dorsolateral striatum. The neural mechanisms underlying this functional transition from recreational drug use to drug-seeking habits are unknown. Here we combined functional disconnections and electrophysiological recordings of the amygdalo-striatal networks in rats trained to seek cocaine to demonstrate that functional shifts within the striatum are driven by transitions from the basolateral (BLA) to the central (CeN) amygdala. Thus, while the recruitment of dorsolateral striatum dopamine-dependent control over cocaine seeking is triggered by the BLA, its long-term maintenance depends instead on the CeN. These data demonstrate that limbic cortical areas both tune the function of cognitive territories of the striatum and thereby underpin maladaptive cocaine-seeking habits.
publisher	Nature Publishing Group
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682035/
_version_	1613513654096887808

Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits

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