A small molecule compound IMB-LA inhibits HIV-1 infection by preventing viral Vpu from antagonizing the host restriction factor BST-2

A small molecule compound IMB-LA inhibits HIV-1 infection by preventing viral Vpu from antagonizing the host restriction factor BST-2

Human BST-2 inhibits HIV-1 replication by tethering nascent virions to the cell surface. HIV-1 codes Vpu that counteracts BST-2 by down-regulating this restriction factor from the cell surface. This important function makes Vpu a potential therapeutic target. Yet, no agents have been reported to blo...

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Bibliographic Details
Main Authors: Mi, Zeyun, Ding, Jiwei, Zhang, Quan, Zhao, Jianyuan, Ma, Ling, Yu, Haisheng, Liu, Zhenlong, Shan, Guangzhi, Li, Xiaoyu, Zhou, Jinming, Wei, Tao, Zhang, Liguo, Guo, Fei, Liang, Chen, Cen, Shan
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680884/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680884/

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