Rapid Screening for Cognitive Impairment in Parkinson's Disease: A Pilot Study

Aim. This study sought to establish the discriminant validity of a rapid cognitive screen, that is, the National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute protocol, and compare its discriminant validity to the Montreal Cognitive Assessment (MoCA) and...

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Main Authors:	Dong, YanHong, Koay, Way Inn, Yeo, Leonard Leong Litt, Chen, Christopher Li-Hsian, Xu, Jing, Seet, Raymond Chee Seong, Lim, Erle Chuen Hian
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680112/

id	pubmed-4680112
recordtype	oai_dc
spelling	pubmed-46801122015-12-28 Rapid Screening for Cognitive Impairment in Parkinson's Disease: A Pilot Study Dong, YanHong Koay, Way Inn Yeo, Leonard Leong Litt Chen, Christopher Li-Hsian Xu, Jing Seet, Raymond Chee Seong Lim, Erle Chuen Hian Research Article Aim. This study sought to establish the discriminant validity of a rapid cognitive screen, that is, the National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute protocol, and compare its discriminant validity to the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE) in detecting cognitive impairment (CI) in PD patients. Methods. One hundred and one PD patients were recruited from a movement disorders clinic in Singapore and they received the NINDS-CSN 5-minute protocol, MoCA, and MMSE. No cognitive impairment (NCI) was defined as Clinical Dementia Rating (CDR) = 0 and CI was defined as CDR ≥ 0.5. Results. Area under the receiver operating characteristic curve of NINDS-CSN 5-minute protocol was statistically equivalent to MoCA and larger than MMSE (0.86 versus 0.90, P = 0.07; 0.86 versus 0.76, P = 0.03). The sensitivity of NINDS-CSN 5-minute protocol (<9) was statistically equivalent to MoCA (<22) (0.77 versus 0.85, P = 0.13) and superior to MMSE (<24) (0.77 versus 0.52, P < 0.01) in detecting CI, while the specificity of NINDS-CSN 5-minute protocol (<9) was statistically equivalent to MoCA (<22) and MMSE (<24) (0.78 versus 0.88, P = 0.34). Conclusion. The NINDS-CSN 5-minute protocol is time expeditious while remaining statistically equivalent to MoCA and superior to MMSE and therefore is suitable for rapid cognitive screening of CI in PD patients. Hindawi Publishing Corporation 2015 2015-12-02 /pmc/articles/PMC4680112/ /pubmed/26713170 http://dx.doi.org/10.1155/2015/348063 Text en Copyright © 2015 YanHong Dong et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Dong, YanHong Koay, Way Inn Yeo, Leonard Leong Litt Chen, Christopher Li-Hsian Xu, Jing Seet, Raymond Chee Seong Lim, Erle Chuen Hian
spellingShingle	Dong, YanHong Koay, Way Inn Yeo, Leonard Leong Litt Chen, Christopher Li-Hsian Xu, Jing Seet, Raymond Chee Seong Lim, Erle Chuen Hian Rapid Screening for Cognitive Impairment in Parkinson's Disease: A Pilot Study
author_facet	Dong, YanHong Koay, Way Inn Yeo, Leonard Leong Litt Chen, Christopher Li-Hsian Xu, Jing Seet, Raymond Chee Seong Lim, Erle Chuen Hian
author_sort	Dong, YanHong
title	Rapid Screening for Cognitive Impairment in Parkinson's Disease: A Pilot Study
title_short	Rapid Screening for Cognitive Impairment in Parkinson's Disease: A Pilot Study
title_full	Rapid Screening for Cognitive Impairment in Parkinson's Disease: A Pilot Study
title_fullStr	Rapid Screening for Cognitive Impairment in Parkinson's Disease: A Pilot Study
title_full_unstemmed	Rapid Screening for Cognitive Impairment in Parkinson's Disease: A Pilot Study
title_sort	rapid screening for cognitive impairment in parkinson's disease: a pilot study
description	Aim. This study sought to establish the discriminant validity of a rapid cognitive screen, that is, the National Institute of Neurological Disease and Stroke-Canadian Stroke Network (NINDS-CSN) 5-minute protocol, and compare its discriminant validity to the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE) in detecting cognitive impairment (CI) in PD patients. Methods. One hundred and one PD patients were recruited from a movement disorders clinic in Singapore and they received the NINDS-CSN 5-minute protocol, MoCA, and MMSE. No cognitive impairment (NCI) was defined as Clinical Dementia Rating (CDR) = 0 and CI was defined as CDR ≥ 0.5. Results. Area under the receiver operating characteristic curve of NINDS-CSN 5-minute protocol was statistically equivalent to MoCA and larger than MMSE (0.86 versus 0.90, P = 0.07; 0.86 versus 0.76, P = 0.03). The sensitivity of NINDS-CSN 5-minute protocol (<9) was statistically equivalent to MoCA (<22) (0.77 versus 0.85, P = 0.13) and superior to MMSE (<24) (0.77 versus 0.52, P < 0.01) in detecting CI, while the specificity of NINDS-CSN 5-minute protocol (<9) was statistically equivalent to MoCA (<22) and MMSE (<24) (0.78 versus 0.88, P = 0.34). Conclusion. The NINDS-CSN 5-minute protocol is time expeditious while remaining statistically equivalent to MoCA and superior to MMSE and therefore is suitable for rapid cognitive screening of CI in PD patients.
publisher	Hindawi Publishing Corporation
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680112/
_version_	1613513180934307840

Rapid Screening for Cognitive Impairment in Parkinson's Disease: A Pilot Study

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