Molecular Mechanisms of Action of BPA

Bisphenol A (BPA) exposure has been associated with serious endocrine-disrupting effects in humans and wildlife. Toxicological and epidemiological studies evidenced that BPA increases body mass index and disrupts normal cardiovascular physiology by interfering with endogenous hormones in rodents, no...

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Main Authors:	Acconcia, Filippo, Pallottini, Valentina, Marino, Maria
Format:	Online
Language:	English
Published:	SAGE Publications 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679188/

id	pubmed-4679188
recordtype	oai_dc
spelling	pubmed-46791882016-01-06 Molecular Mechanisms of Action of BPA Acconcia, Filippo Pallottini, Valentina Marino, Maria Article Bisphenol A (BPA) exposure has been associated with serious endocrine-disrupting effects in humans and wildlife. Toxicological and epidemiological studies evidenced that BPA increases body mass index and disrupts normal cardiovascular physiology by interfering with endogenous hormones in rodents, nonhuman primates, and cell culture test systems. The BPA concentration derived from these experiments were used by government regulatory agencies to determine the safe exposure levels of BPA in humans. However, accumulating literature in vivo and in vitro indicate that at concentrations lower than that reported in toxicological studies, BPA could elicit a different endocrine-disrupting capacity. To further complicate this picture, BPA effects rely on several and diverse mechanisms that converge upon endocrine and reproductive systems. If all or just few of these mechanisms concur to the endocrine-disrupting potential of low doses of BPA is at present still unclear. Thus, taking into account that the incidence and/or prevalence of health problems associated with endocrine disruption have increased worldwide, the goal of the present review is to give an overview of the many mechanisms of BPA action in order to decipher whether different mechanisms are at the root of the effect of low dose of BPA on endocrine system. SAGE Publications 2015-10-07 /pmc/articles/PMC4679188/ /pubmed/26740804 http://dx.doi.org/10.1177/1559325815610582 Text en © The Author(s) 2015 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Acconcia, Filippo Pallottini, Valentina Marino, Maria
spellingShingle	Acconcia, Filippo Pallottini, Valentina Marino, Maria Molecular Mechanisms of Action of BPA
author_facet	Acconcia, Filippo Pallottini, Valentina Marino, Maria
author_sort	Acconcia, Filippo
title	Molecular Mechanisms of Action of BPA
title_short	Molecular Mechanisms of Action of BPA
title_full	Molecular Mechanisms of Action of BPA
title_fullStr	Molecular Mechanisms of Action of BPA
title_full_unstemmed	Molecular Mechanisms of Action of BPA
title_sort	molecular mechanisms of action of bpa
description	Bisphenol A (BPA) exposure has been associated with serious endocrine-disrupting effects in humans and wildlife. Toxicological and epidemiological studies evidenced that BPA increases body mass index and disrupts normal cardiovascular physiology by interfering with endogenous hormones in rodents, nonhuman primates, and cell culture test systems. The BPA concentration derived from these experiments were used by government regulatory agencies to determine the safe exposure levels of BPA in humans. However, accumulating literature in vivo and in vitro indicate that at concentrations lower than that reported in toxicological studies, BPA could elicit a different endocrine-disrupting capacity. To further complicate this picture, BPA effects rely on several and diverse mechanisms that converge upon endocrine and reproductive systems. If all or just few of these mechanisms concur to the endocrine-disrupting potential of low doses of BPA is at present still unclear. Thus, taking into account that the incidence and/or prevalence of health problems associated with endocrine disruption have increased worldwide, the goal of the present review is to give an overview of the many mechanisms of BPA action in order to decipher whether different mechanisms are at the root of the effect of low dose of BPA on endocrine system.
publisher	SAGE Publications
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679188/
_version_	1613512970581573632

Molecular Mechanisms of Action of BPA

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