Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis

Background and Aims. It is widely accepted that obstructive sleep apnea (OSA) is independently associated with atherosclerosis. Similar to OSA, hypertension (HTN) is a condition associated with atherosclerosis. However, to date, the impact of the simultaneous presence of OSA and HTN on the risk of...

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Main Authors:	Damiani, Mario Francesco, Zito, Annapaola, Carratù, Pierluigi, Falcone, Vito Antonio, Bega, Elioda, Scicchitano, Pietro, Ciccone, Marco Matteo, Resta, Onofrio
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678058/

id	pubmed-4678058
recordtype	oai_dc
spelling	pubmed-46780582015-12-22 Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis Damiani, Mario Francesco Zito, Annapaola Carratù, Pierluigi Falcone, Vito Antonio Bega, Elioda Scicchitano, Pietro Ciccone, Marco Matteo Resta, Onofrio Research Article Background and Aims. It is widely accepted that obstructive sleep apnea (OSA) is independently associated with atherosclerosis. Similar to OSA, hypertension (HTN) is a condition associated with atherosclerosis. However, to date, the impact of the simultaneous presence of OSA and HTN on the risk of atherosclerosis has not been extensively studied. The aim of this study was to evaluate the consequences of the coexistence of OSA and HTN on carotid intima-media thickness (IMT) and on inflammatory markers of atherosclerosis (such as interleukin- [IL-] 6 and pentraxin- [PTX-] 3). Methods. The study design allowed us to define 4 groups: (1) controls (n = 30); (2) OSA patients without HTN (n = 30); (3) HTN patients without OSA (n = 30); (4) patients with OSA and HTN (n = 30). In the morning after portable monitoring (between 7 am and 8 am), blood samples were collected, and carotid IMT was measured. Results. Carotid IMT, IL-6, and PTX-3 in OSA normotensive patients and in non-OSA HTN subjects were significantly higher compared to control subjects; in addition, in OSA hypertensive patients they were significantly increased compared to OSA normotensive, non-OSA HTN, or control subjects. Conclusions. OSA and HTN have an additive role in the progression of carotid atherosclerosis and in blood levels of inflammatory markers for atherosclerosis, such as interleukin-6 and pentraxin-3. Hindawi Publishing Corporation 2015 2015-12-01 /pmc/articles/PMC4678058/ /pubmed/26697221 http://dx.doi.org/10.1155/2015/984193 Text en Copyright © 2015 Mario Francesco Damiani et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Damiani, Mario Francesco Zito, Annapaola Carratù, Pierluigi Falcone, Vito Antonio Bega, Elioda Scicchitano, Pietro Ciccone, Marco Matteo Resta, Onofrio
spellingShingle	Damiani, Mario Francesco Zito, Annapaola Carratù, Pierluigi Falcone, Vito Antonio Bega, Elioda Scicchitano, Pietro Ciccone, Marco Matteo Resta, Onofrio Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis
author_facet	Damiani, Mario Francesco Zito, Annapaola Carratù, Pierluigi Falcone, Vito Antonio Bega, Elioda Scicchitano, Pietro Ciccone, Marco Matteo Resta, Onofrio
author_sort	Damiani, Mario Francesco
title	Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis
title_short	Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis
title_full	Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis
title_fullStr	Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis
title_full_unstemmed	Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis
title_sort	obstructive sleep apnea, hypertension, and their additive effects on atherosclerosis
description	Background and Aims. It is widely accepted that obstructive sleep apnea (OSA) is independently associated with atherosclerosis. Similar to OSA, hypertension (HTN) is a condition associated with atherosclerosis. However, to date, the impact of the simultaneous presence of OSA and HTN on the risk of atherosclerosis has not been extensively studied. The aim of this study was to evaluate the consequences of the coexistence of OSA and HTN on carotid intima-media thickness (IMT) and on inflammatory markers of atherosclerosis (such as interleukin- [IL-] 6 and pentraxin- [PTX-] 3). Methods. The study design allowed us to define 4 groups: (1) controls (n = 30); (2) OSA patients without HTN (n = 30); (3) HTN patients without OSA (n = 30); (4) patients with OSA and HTN (n = 30). In the morning after portable monitoring (between 7 am and 8 am), blood samples were collected, and carotid IMT was measured. Results. Carotid IMT, IL-6, and PTX-3 in OSA normotensive patients and in non-OSA HTN subjects were significantly higher compared to control subjects; in addition, in OSA hypertensive patients they were significantly increased compared to OSA normotensive, non-OSA HTN, or control subjects. Conclusions. OSA and HTN have an additive role in the progression of carotid atherosclerosis and in blood levels of inflammatory markers for atherosclerosis, such as interleukin-6 and pentraxin-3.
publisher	Hindawi Publishing Corporation
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678058/
_version_	1613512573888495616

Obstructive Sleep Apnea, Hypertension, and Their Additive Effects on Atherosclerosis

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