Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation

Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after x-irradiation

The role of mitochondrial dynamics in cellular responses to ionizing radiation (IR) is still largely unknown. This study demonstrates that IR triggers Drp1-dependent mitochondrial fission and that Drp1 inhibition attenuates radiation-induced mitotic catastrophe, suggesting that Drp1 is involved in d...

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Bibliographic Details
Main Authors: Yamamori, Tohru, Ike, Satoshi, Bo, Tomoki, Sasagawa, Tomoya, Sakai, Yuri, Suzuki, Motofumi, Yamamoto, Kumiko, Nagane, Masaki, Yasui, Hironobu, Inanami, Osamu
Format: Online
Language:English
Published: The American Society for Cell Biology 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678018/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678018/

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