Incidence of Pneumococcal Pneumonia among Adults in Rural Thailand, 2006–2011: Implications for Pneumococcal Vaccine Considerations

Incidence of Pneumococcal Pneumonia among Adults in Rural Thailand, 2006–2011: Implications for Pneumococcal Vaccine Considerations

The incidence of pneumococcal pneumonia among adults is a key driver for the cost-effectiveness of pneumococcal conjugate vaccine used among children. We sought to obtain more accurate incidence estimates among adults by including results of pneumococcal urine antigen testing (UAT) from population-b...

Full description

Bibliographic Details
Main Authors: Piralam, Barameht, Tomczyk, Sara M., Rhodes, Julia C., Thamthitiwat, Somsak, Gregory, Christopher J., Olsen, Sonja J., Praphasiri, Prabda, Sawatwong, Pongpun, Naorat, Sathapana, Chantra, Somrak, Areerat, Peera, Hurst, Cameron P., Moore, Matthew R., Muangchana, Charung, Baggett, Henry C.
Format: Online
Language:English
Published: The American Society of Tropical Medicine and Hygiene 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674225/
id pubmed-4674225
recordtype oai_dc
spelling pubmed-46742252015-12-16 Incidence of Pneumococcal Pneumonia among Adults in Rural Thailand, 2006–2011: Implications for Pneumococcal Vaccine Considerations Piralam, Barameht Tomczyk, Sara M. Rhodes, Julia C. Thamthitiwat, Somsak Gregory, Christopher J. Olsen, Sonja J. Praphasiri, Prabda Sawatwong, Pongpun Naorat, Sathapana Chantra, Somrak Areerat, Peera Hurst, Cameron P. Moore, Matthew R. Muangchana, Charung Baggett, Henry C. Articles The incidence of pneumococcal pneumonia among adults is a key driver for the cost-effectiveness of pneumococcal conjugate vaccine used among children. We sought to obtain more accurate incidence estimates among adults by including results of pneumococcal urine antigen testing (UAT) from population-based pneumonia surveillance in two Thai provinces. Active surveillance from 2006 to 2011 identified acute lower respiratory infection (ALRI)–related hospital admissions. Adult cases of pneumococcal pneumonia were defined as hospitalized ALRI patients aged ≥ 18 years with isolation of Streptococcus pneumoniae from blood or with positive UAT. Among 39,525 adult ALRI patients, we identified 481 pneumococcal pneumonia cases (105 by blood culture, 376 by UAT only). Estimated incidence of pneumococcal pneumonia hospitalizations was 30.5 cases per 100,000 persons per year (2.2 and 28.3 cases per 100,000 persons per year by blood culture and UAT, respectively). Incidence varied between 22.7 in 2007 and 43.5 in 2010, and increased with age to over 150 per 100,000 persons per year among persons aged ≥ 70 years. Viral coinfections including influenza A/B, respiratory syncytial virus (RSV), and adenovirus occurred in 11% (44/409) of pneumococcal pneumonia cases tested. Use of UAT to identify cases of pneumococcal pneumonia among adults in rural Thailand substantially increases estimates of pneumococcal pneumonia burden, thereby informing cost-effectiveness analyses and vaccine policy decisions. The American Society of Tropical Medicine and Hygiene 2015-12-09 /pmc/articles/PMC4674225/ /pubmed/26503277 http://dx.doi.org/10.4269/ajtmh.15-0429 Text en ©The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Piralam, Barameht
Tomczyk, Sara M.
Rhodes, Julia C.
Thamthitiwat, Somsak
Gregory, Christopher J.
Olsen, Sonja J.
Praphasiri, Prabda
Sawatwong, Pongpun
Naorat, Sathapana
Chantra, Somrak
Areerat, Peera
Hurst, Cameron P.
Moore, Matthew R.
Muangchana, Charung
Baggett, Henry C.
spellingShingle Piralam, Barameht
Tomczyk, Sara M.
Rhodes, Julia C.
Thamthitiwat, Somsak
Gregory, Christopher J.
Olsen, Sonja J.
Praphasiri, Prabda
Sawatwong, Pongpun
Naorat, Sathapana
Chantra, Somrak
Areerat, Peera
Hurst, Cameron P.
Moore, Matthew R.
Muangchana, Charung
Baggett, Henry C.
Incidence of Pneumococcal Pneumonia among Adults in Rural Thailand, 2006–2011: Implications for Pneumococcal Vaccine Considerations
author_facet Piralam, Barameht
Tomczyk, Sara M.
Rhodes, Julia C.
Thamthitiwat, Somsak
Gregory, Christopher J.
Olsen, Sonja J.
Praphasiri, Prabda
Sawatwong, Pongpun
Naorat, Sathapana
Chantra, Somrak
Areerat, Peera
Hurst, Cameron P.
Moore, Matthew R.
Muangchana, Charung
Baggett, Henry C.
author_sort Piralam, Barameht
title Incidence of Pneumococcal Pneumonia among Adults in Rural Thailand, 2006–2011: Implications for Pneumococcal Vaccine Considerations
title_short Incidence of Pneumococcal Pneumonia among Adults in Rural Thailand, 2006–2011: Implications for Pneumococcal Vaccine Considerations
title_full Incidence of Pneumococcal Pneumonia among Adults in Rural Thailand, 2006–2011: Implications for Pneumococcal Vaccine Considerations
title_fullStr Incidence of Pneumococcal Pneumonia among Adults in Rural Thailand, 2006–2011: Implications for Pneumococcal Vaccine Considerations
title_full_unstemmed Incidence of Pneumococcal Pneumonia among Adults in Rural Thailand, 2006–2011: Implications for Pneumococcal Vaccine Considerations
title_sort incidence of pneumococcal pneumonia among adults in rural thailand, 2006–2011: implications for pneumococcal vaccine considerations
description The incidence of pneumococcal pneumonia among adults is a key driver for the cost-effectiveness of pneumococcal conjugate vaccine used among children. We sought to obtain more accurate incidence estimates among adults by including results of pneumococcal urine antigen testing (UAT) from population-based pneumonia surveillance in two Thai provinces. Active surveillance from 2006 to 2011 identified acute lower respiratory infection (ALRI)–related hospital admissions. Adult cases of pneumococcal pneumonia were defined as hospitalized ALRI patients aged ≥ 18 years with isolation of Streptococcus pneumoniae from blood or with positive UAT. Among 39,525 adult ALRI patients, we identified 481 pneumococcal pneumonia cases (105 by blood culture, 376 by UAT only). Estimated incidence of pneumococcal pneumonia hospitalizations was 30.5 cases per 100,000 persons per year (2.2 and 28.3 cases per 100,000 persons per year by blood culture and UAT, respectively). Incidence varied between 22.7 in 2007 and 43.5 in 2010, and increased with age to over 150 per 100,000 persons per year among persons aged ≥ 70 years. Viral coinfections including influenza A/B, respiratory syncytial virus (RSV), and adenovirus occurred in 11% (44/409) of pneumococcal pneumonia cases tested. Use of UAT to identify cases of pneumococcal pneumonia among adults in rural Thailand substantially increases estimates of pneumococcal pneumonia burden, thereby informing cost-effectiveness analyses and vaccine policy decisions.
publisher The American Society of Tropical Medicine and Hygiene
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674225/
_version_ 1613511346941329408

Similar Items