Exploring the Y Chromosomal Ancestry of Modern Panamanians

Geologically, Panama belongs to the Central American land-bridge between North and South America crossed by Homo sapiens >14 ka ago. Archaeologically, it belongs to a wider Isthmo-Colombian Area. Today, seven indigenous ethnic groups account for 12.3% of Panama’s population. Five speak Chibchan l...

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Main Authors:	Grugni, Viola, Battaglia, Vincenza, Perego, Ugo Alessandro, Raveane, Alessandro, Lancioni, Hovirag, Olivieri, Anna, Ferretti, Luca, Woodward, Scott R., Pascale, Juan Miguel, Cooke, Richard, Myres, Natalie, Motta, Jorge, Torroni, Antonio, Achilli, Alessandro, Semino, Ornella
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670172/

id	pubmed-4670172
recordtype	oai_dc
spelling	pubmed-46701722015-12-10 Exploring the Y Chromosomal Ancestry of Modern Panamanians Grugni, Viola Battaglia, Vincenza Perego, Ugo Alessandro Raveane, Alessandro Lancioni, Hovirag Olivieri, Anna Ferretti, Luca Woodward, Scott R. Pascale, Juan Miguel Cooke, Richard Myres, Natalie Motta, Jorge Torroni, Antonio Achilli, Alessandro Semino, Ornella Research Article Geologically, Panama belongs to the Central American land-bridge between North and South America crossed by Homo sapiens >14 ka ago. Archaeologically, it belongs to a wider Isthmo-Colombian Area. Today, seven indigenous ethnic groups account for 12.3% of Panama’s population. Five speak Chibchan languages and are characterized by low genetic diversity and a high level of differentiation. In addition, no evidence of differential structuring between maternally and paternally inherited genes has been reported in isthmian Chibchan cultural groups. Recent data have shown that 83% of the Panamanian general population harbour mitochondrial DNAs (mtDNAs) of Native American ancestry. Considering differential male/female mortality at European contact and multiple degrees of geographical and genetic isolation over the subsequent five centuries, the Y-chromosome Native American component is expected to vary across different geographic regions and communities in Panama. To address this issue, we investigated Y-chromosome variation in 408 modern males from the nine provinces of Panama and one indigenous territory (the comarca of Kuna Yala). In contrast to mtDNA data, the Y-chromosome Native American component (haplogroup Q) exceeds 50% only in three populations facing the Caribbean Sea: the comarca of Kuna Yala and Bocas del Toro province where Chibchan languages are spoken by the majority, and the province of Colón where many Kuna and people of mixed indigenous-African-and-European descent live. Elsewhere the Old World component is dominant and mostly represented by western Eurasian haplogroups, which signal the strong male genetic impact of invaders. Sub-Saharan African input accounts for 5.9% of male haplotypes. This reflects the consequences of the colonial Atlantic slave trade and more recent influxes of West Indians of African heritage. Overall, our findings reveal a local evolution of the male Native American ancestral gene pool, and a strong but geographically differentiated unidirectional sex bias in the formation of local modern Panamanian populations. Public Library of Science 2015-12-04 /pmc/articles/PMC4670172/ /pubmed/26636572 http://dx.doi.org/10.1371/journal.pone.0144223 Text en © 2015 Grugni et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Grugni, Viola Battaglia, Vincenza Perego, Ugo Alessandro Raveane, Alessandro Lancioni, Hovirag Olivieri, Anna Ferretti, Luca Woodward, Scott R. Pascale, Juan Miguel Cooke, Richard Myres, Natalie Motta, Jorge Torroni, Antonio Achilli, Alessandro Semino, Ornella
spellingShingle	Grugni, Viola Battaglia, Vincenza Perego, Ugo Alessandro Raveane, Alessandro Lancioni, Hovirag Olivieri, Anna Ferretti, Luca Woodward, Scott R. Pascale, Juan Miguel Cooke, Richard Myres, Natalie Motta, Jorge Torroni, Antonio Achilli, Alessandro Semino, Ornella Exploring the Y Chromosomal Ancestry of Modern Panamanians
author_facet	Grugni, Viola Battaglia, Vincenza Perego, Ugo Alessandro Raveane, Alessandro Lancioni, Hovirag Olivieri, Anna Ferretti, Luca Woodward, Scott R. Pascale, Juan Miguel Cooke, Richard Myres, Natalie Motta, Jorge Torroni, Antonio Achilli, Alessandro Semino, Ornella
author_sort	Grugni, Viola
title	Exploring the Y Chromosomal Ancestry of Modern Panamanians
title_short	Exploring the Y Chromosomal Ancestry of Modern Panamanians
title_full	Exploring the Y Chromosomal Ancestry of Modern Panamanians
title_fullStr	Exploring the Y Chromosomal Ancestry of Modern Panamanians
title_full_unstemmed	Exploring the Y Chromosomal Ancestry of Modern Panamanians
title_sort	exploring the y chromosomal ancestry of modern panamanians
description	Geologically, Panama belongs to the Central American land-bridge between North and South America crossed by Homo sapiens >14 ka ago. Archaeologically, it belongs to a wider Isthmo-Colombian Area. Today, seven indigenous ethnic groups account for 12.3% of Panama’s population. Five speak Chibchan languages and are characterized by low genetic diversity and a high level of differentiation. In addition, no evidence of differential structuring between maternally and paternally inherited genes has been reported in isthmian Chibchan cultural groups. Recent data have shown that 83% of the Panamanian general population harbour mitochondrial DNAs (mtDNAs) of Native American ancestry. Considering differential male/female mortality at European contact and multiple degrees of geographical and genetic isolation over the subsequent five centuries, the Y-chromosome Native American component is expected to vary across different geographic regions and communities in Panama. To address this issue, we investigated Y-chromosome variation in 408 modern males from the nine provinces of Panama and one indigenous territory (the comarca of Kuna Yala). In contrast to mtDNA data, the Y-chromosome Native American component (haplogroup Q) exceeds 50% only in three populations facing the Caribbean Sea: the comarca of Kuna Yala and Bocas del Toro province where Chibchan languages are spoken by the majority, and the province of Colón where many Kuna and people of mixed indigenous-African-and-European descent live. Elsewhere the Old World component is dominant and mostly represented by western Eurasian haplogroups, which signal the strong male genetic impact of invaders. Sub-Saharan African input accounts for 5.9% of male haplotypes. This reflects the consequences of the colonial Atlantic slave trade and more recent influxes of West Indians of African heritage. Overall, our findings reveal a local evolution of the male Native American ancestral gene pool, and a strong but geographically differentiated unidirectional sex bias in the formation of local modern Panamanian populations.
publisher	Public Library of Science
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670172/
_version_	1613509748587495424

Exploring the Y Chromosomal Ancestry of Modern Panamanians

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