Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice

Ageing is a complex biological process for which underlying biochemical changes are still largely unknown. We performed comparative profiling of the cellular proteome and metabolome to understand the molecular basis of ageing in Caspase-2-deficient (Casp2−/−) mice that are a model of premature agein...

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Bibliographic Details
Main Authors: Wilson, C H, Shalini, S, Filipovska, A, Richman, T R, Davies, S, Martin, S D, McGee, S L, Puccini, J, Nikolic, A, Dorstyn, L, Kumar, S
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669765/