Differential evolution of a CXCR4-using HIV-1 strain in CCR5wt/wt and CCR5∆32/∆32 hosts revealed by longitudinal deep sequencing and phylogenetic reconstruction

Differential evolution of a CXCR4-using HIV-1 strain in CCR5wt/wt and CCR5∆32/∆32 hosts revealed by longitudinal deep sequencing and phylogenetic reconstruction

Rare individuals homozygous for a naturally-occurring 32 base pair deletion in the CCR5 gene (CCR5∆32/∆32) are resistant to infection by CCR5-using (“R5”) HIV-1 strains but remain susceptible to less common CXCR4-using (“X4”) strains. The evolutionary dynamics of X4 infections however, remain incomp...

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Bibliographic Details
Main Authors: Le, Anh Q., Taylor, Jeremy, Dong, Winnie, McCloskey, Rosemary, Woods, Conan, Danroth, Ryan, Hayashi, Kanna, Milloy, M.-J., Poon, Art F. Y., Brumme, Zabrina L.
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668558/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668558/

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