Molecular Targets in Alzheimer's Disease: From Pathogenesis to Therapeutics
Alzheimer's disease (AD) is characterized by progressive cognitive decline usually beginning with impairment in the ability to form recent memories. Nonavailability of definitive therapeutic strategy urges developing pharmacological targets based on cell signaling pathways. A great revival of...
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| Format: | Online |
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Hindawi Publishing Corporation
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668300/ |
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pubmed-46683002015-12-10 Molecular Targets in Alzheimer's Disease: From Pathogenesis to Therapeutics Cheng, Xuan Zhang, Lu Lian, Ya-Jun Review Article Alzheimer's disease (AD) is characterized by progressive cognitive decline usually beginning with impairment in the ability to form recent memories. Nonavailability of definitive therapeutic strategy urges developing pharmacological targets based on cell signaling pathways. A great revival of interest in nutraceuticals and adjuvant therapy has been put forward. Tea polyphenols for their multiple health benefits have also attracted the attention of researchers. Tea catechins showed enough potentiality to be used in future as therapeutic targets to provide neuroprotection against AD. This review attempts to present a concise map of different receptor signaling pathways associated with AD with an insight into drug designing based on the proposed signaling pathways, molecular mechanistic details of AD pathogenesis, and a scientific rationale for using tea polyphenols as proposed therapeutic agents in AD. Hindawi Publishing Corporation 2015 2015-11-19 /pmc/articles/PMC4668300/ /pubmed/26665008 http://dx.doi.org/10.1155/2015/760758 Text en Copyright © 2015 Xuan Cheng et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Cheng, Xuan Zhang, Lu Lian, Ya-Jun |
| spellingShingle |
Cheng, Xuan Zhang, Lu Lian, Ya-Jun Molecular Targets in Alzheimer's Disease: From Pathogenesis to Therapeutics |
| author_facet |
Cheng, Xuan Zhang, Lu Lian, Ya-Jun |
| author_sort |
Cheng, Xuan |
| title |
Molecular Targets in Alzheimer's Disease: From Pathogenesis to Therapeutics |
| title_short |
Molecular Targets in Alzheimer's Disease: From Pathogenesis to Therapeutics |
| title_full |
Molecular Targets in Alzheimer's Disease: From Pathogenesis to Therapeutics |
| title_fullStr |
Molecular Targets in Alzheimer's Disease: From Pathogenesis to Therapeutics |
| title_full_unstemmed |
Molecular Targets in Alzheimer's Disease: From Pathogenesis to Therapeutics |
| title_sort |
molecular targets in alzheimer's disease: from pathogenesis to therapeutics |
| description |
Alzheimer's disease (AD) is characterized by progressive cognitive decline usually beginning with impairment in the ability to form recent memories. Nonavailability of definitive therapeutic strategy urges developing pharmacological targets based on cell signaling pathways. A great revival of interest in nutraceuticals and adjuvant therapy has been put forward. Tea polyphenols for their multiple health benefits have also attracted the attention of researchers. Tea catechins showed enough potentiality to be used in future as therapeutic targets to provide neuroprotection against AD. This review attempts to present a concise map of different receptor signaling pathways associated with AD with an insight into drug designing based on the proposed signaling pathways, molecular mechanistic details of AD pathogenesis, and a scientific rationale for using tea polyphenols as proposed therapeutic agents in AD. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668300/ |
| _version_ |
1613509111391977472 |