A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase

A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase

During G1-phase of the cell-cycle the replicative MCM2–7 helicase becomes loaded onto DNA into pre-replicative complexes (pre-RCs), resulting in MCM2–7 double-hexamers on DNA. In S-phase, Dbf4-dependent kinase (DDK) and cyclin-dependent-kinase (CDK) direct with the help of a large number of helicase...

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Bibliographic Details
Main Authors: Herrera, M. Carmen, Tognetti, Silvia, Riera, Alberto, Zech, Juergen, Clarke, Pippa, Fernández-Cid, Alejandra, Speck, Christian
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666391/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666391/

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