A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection

The present study aimed to identify the risk factors influencing the survival of patients with hepatocellular carcinoma (HCC) affected by portal vein tumor thrombus (PVTT), following hepatic resection, and to establish a prognostic model. Between March 2001 and May 2008, 234 cases of HCC with PVTT t...

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Main Authors:	XIAO, CHENG-ZUO, WEI, WEI, GUO, ZHI-XING, LI, SHU-HONG, ZHANG, YONG-FA, WANG, JIA-HONG, SHI, MING, GUO, RONG-PING
Format:	Online
Language:	English
Published:	D.A. Spandidos 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665632/

id	pubmed-4665632
recordtype	oai_dc
spelling	pubmed-46656322015-12-31 A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection XIAO, CHENG-ZUO WEI, WEI GUO, ZHI-XING LI, SHU-HONG ZHANG, YONG-FA WANG, JIA-HONG SHI, MING GUO, RONG-PING Articles The present study aimed to identify the risk factors influencing the survival of patients with hepatocellular carcinoma (HCC) affected by portal vein tumor thrombus (PVTT), following hepatic resection, and to establish a prognostic model. Between March 2001 and May 2008, 234 cases of HCC with PVTT that underwent hepatic resection were randomly divided into experimental or validation groups. The association between the clinicopathological factors and disease-free survival (DFS) and overall survival (OS) was analyzed, and the significant factors involved were used to establish a prognostic model, which was then validated. Tumor rupture, number of tumors and macroscopic vascular invasion were observed to be independent risk factors of DFS and OS. In the prognostic model, the DFS and OS of low-, medium- and high-risk patients in the experimental group were observed to be significantly different, compared to those in the validation group. In conclusion, the present study established a prognostic model for patients with HCC affected by PVTT following hepatectomy, and demonstrated that the model may be used to guide the treatment of these patients and predict their prognosis. D.A. Spandidos 2015-11 2015-09-03 /pmc/articles/PMC4665632/ /pubmed/26722243 http://dx.doi.org/10.3892/ol.2015.3677 Text en Copyright: © Xiao et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	XIAO, CHENG-ZUO WEI, WEI GUO, ZHI-XING LI, SHU-HONG ZHANG, YONG-FA WANG, JIA-HONG SHI, MING GUO, RONG-PING
spellingShingle	XIAO, CHENG-ZUO WEI, WEI GUO, ZHI-XING LI, SHU-HONG ZHANG, YONG-FA WANG, JIA-HONG SHI, MING GUO, RONG-PING A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection
author_facet	XIAO, CHENG-ZUO WEI, WEI GUO, ZHI-XING LI, SHU-HONG ZHANG, YONG-FA WANG, JIA-HONG SHI, MING GUO, RONG-PING
author_sort	XIAO, CHENG-ZUO
title	A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection
title_short	A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection
title_full	A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection
title_fullStr	A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection
title_full_unstemmed	A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection
title_sort	prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection
description	The present study aimed to identify the risk factors influencing the survival of patients with hepatocellular carcinoma (HCC) affected by portal vein tumor thrombus (PVTT), following hepatic resection, and to establish a prognostic model. Between March 2001 and May 2008, 234 cases of HCC with PVTT that underwent hepatic resection were randomly divided into experimental or validation groups. The association between the clinicopathological factors and disease-free survival (DFS) and overall survival (OS) was analyzed, and the significant factors involved were used to establish a prognostic model, which was then validated. Tumor rupture, number of tumors and macroscopic vascular invasion were observed to be independent risk factors of DFS and OS. In the prognostic model, the DFS and OS of low-, medium- and high-risk patients in the experimental group were observed to be significantly different, compared to those in the validation group. In conclusion, the present study established a prognostic model for patients with HCC affected by PVTT following hepatectomy, and demonstrated that the model may be used to guide the treatment of these patients and predict their prognosis.
publisher	D.A. Spandidos
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665632/
_version_	1613508241511153664

A prognosis model for patients with hepatocellular carcinoma and portal vein tumor thrombus following hepatic resection

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