Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease

Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) has become a predictive factor of death from many diseases. Farnesoid X receptor (FXR) is an ideal target for NAFLD drug development due to its crucial roles in lipid metabolism. The aim of this work is to examine the molecular mechanisms and functional role...

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Bibliographic Details
Main Authors: Jin, Lihua, Wang, Rui, Zhu, Yanlin, Zheng, Weili, Han, Yaping, Guo, Fusheng, Ye, Frank Bin, Li, Yong
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664883/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664883/

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