Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis

Osteoarthritis (OA), a degenerative joint condition, is currently difficult to detect early enough for any of the current treatment options to be completely successful. Early diagnosis of this disease could increase the numbers of patients who are able to slow its progression. There are now several...

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Main Authors:	Lewis, Rebecca, Barrett-Jolley, Richard
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664663/

id	pubmed-4664663
recordtype	oai_dc
spelling	pubmed-46646632015-12-08 Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis Lewis, Rebecca Barrett-Jolley, Richard Physiology Osteoarthritis (OA), a degenerative joint condition, is currently difficult to detect early enough for any of the current treatment options to be completely successful. Early diagnosis of this disease could increase the numbers of patients who are able to slow its progression. There are now several diseases where membrane protein biomarkers are used for early diagnosis. The numbers of proteins in the membrane is vast and so it is a rich source of potential biomarkers for OA but we need more knowledge of these before they can be considered practical biomarkers. How are they best measured and are they selective to OA or even certain types of OA? The first step in this process is to identify membrane proteins that change in OA. Here, we summarize several ion channels and receptors that change in OA models and/or OA patients, and may thus be considered candidates as novel membrane biomarkers of OA. Frontiers Media S.A. 2015-12-01 /pmc/articles/PMC4664663/ /pubmed/26648874 http://dx.doi.org/10.3389/fphys.2015.00357 Text en Copyright © 2015 Lewis and Barrett-Jolley. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lewis, Rebecca Barrett-Jolley, Richard
spellingShingle	Lewis, Rebecca Barrett-Jolley, Richard Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis
author_facet	Lewis, Rebecca Barrett-Jolley, Richard
author_sort	Lewis, Rebecca
title	Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis
title_short	Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis
title_full	Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis
title_fullStr	Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis
title_full_unstemmed	Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis
title_sort	changes in membrane receptors and ion channels as potential biomarkers for osteoarthritis
description	Osteoarthritis (OA), a degenerative joint condition, is currently difficult to detect early enough for any of the current treatment options to be completely successful. Early diagnosis of this disease could increase the numbers of patients who are able to slow its progression. There are now several diseases where membrane protein biomarkers are used for early diagnosis. The numbers of proteins in the membrane is vast and so it is a rich source of potential biomarkers for OA but we need more knowledge of these before they can be considered practical biomarkers. How are they best measured and are they selective to OA or even certain types of OA? The first step in this process is to identify membrane proteins that change in OA. Here, we summarize several ion channels and receptors that change in OA models and/or OA patients, and may thus be considered candidates as novel membrane biomarkers of OA.
publisher	Frontiers Media S.A.
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664663/
_version_	1613507889856512000

Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis

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