Glutamine Synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

Glutamine Synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

L-Glutamine (Gln) functions physiologically to balance tissue requirements of carbon and nitrogen. It has been proposed that in cancer cells undergoing aerobic glycolysis, accelerated anabolism is sustained by Gln-derived carbons, which replenish the tricarboxylic acid (TCA) cycle (anaplerosis). How...

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Bibliographic Details
Main Authors: Tardito, Saverio, Oudin, Anaïs, Ahmed, Shafiq U., Fack, Fred, Keunen, Olivier, Zheng, Liang, Miletic, Hrvoje, Sakariassen, Per Øystein, Weinstock, Adam, Wagner, Allon, Lindsay, Susan L., Hock, Andreas K., Barnett, Susan C., Ruppin, Eytan, Mørkve, Svein Harald, Lund-Johansen, Morten, Chalmers, Anthony J., Bjerkvig, Rolf, Niclou, Simone P., Gottlieb, Eyal
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663685/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663685/

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