Tuning the Phosphoryl Donor Specificity of Dihydroxyacetone Kinase from ATP to Inorganic Polyphosphate. An Insight from Computational Studies

Tuning the Phosphoryl Donor Specificity of Dihydroxyacetone Kinase from ATP to Inorganic Polyphosphate. An Insight from Computational Studies

Dihydroxyacetone (DHA) kinase from Citrobacter freundii provides an easy entry for the preparation of DHA phosphate; a very important C3 building block in nature. To modify the phosphoryl donor specificity of this enzyme from ATP to inorganic polyphosphate (poly-P); a directed evolution program has...

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Bibliographic Details
Main Authors: Sánchez-Moreno, Israel, Bordes, Isabel, Castillo, Raquel, Ruiz-Pernía, José Javier, Moliner, Vicent, García-Junceda, Eduardo
Format: Online
Language:English
Published: MDPI 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661931/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661931/

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