ω-Tbo-IT1–New Inhibitor of Insect Calcium Channels Isolated from Spider Venom

ω-Tbo-IT1–New Inhibitor of Insect Calcium Channels Isolated from Spider Venom

Novel disulfide-containing polypeptide toxin was discovered in the venom of the Tibellus oblongus spider. We report on isolation, spatial structure determination and electrophysiological characterization of this 41-residue toxin, called ω-Tbo-IT1. It has an insect-toxic effect with LD50 19 μg/g in e...

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Bibliographic Details
Main Authors: Mikov, Alexander N., Fedorova, Irina M., Potapieva, Natalia N., Maleeva, Ekaterina E., Andreev, Yaroslav A., Zaitsev, Alexey V., Kim, Kira K., Bocharov, Eduard V., Bozin, Timur N., Altukhov, Dmitry A., Lipkin, Alexey V., Kozlov, Sergey A., Tikhonov, Denis B., Grishin, Eugene V.
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661699/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661699/

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