Cotransfected human chondrocytes: over-expression of IGF-I and SOX9 enhances the synthesis of cartilage matrix components collagen-II and glycosaminoglycans

Cotransfected human chondrocytes: over-expression of IGF-I and SOX9 enhances the synthesis of cartilage matrix components collagen-II and glycosaminoglycans

Damage to cartilage causes a loss of type II collagen (Col-II) and glycosaminoglycans (GAG). To restore the original cartilage architecture, cell factors that stimulate Col-II and GAG production are needed. Insulin-like growth factor I (IGF-I) and transcription factor SOX9are essential for the synth...

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Bibliographic Details
Main Authors: Simental-Mendía, M., Lara-Arias, J., Álvarez-Lozano, E., Said-Fernández, S., Soto-Domínguez, A., Padilla-Rivas, G. R., Martínez-Rodríguez, H. G.
Format: Online
Language:English
Published: Associação Brasileira de Divulgação Científica 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661021/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661021/

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