Coupling of α,α-difluoro-substituted organozinc reagents with 1-bromoalkynes
α,α-Difluoro-substituted organozinc reagents generated from conventional organozinc compounds and difluorocarbene couple with 1-bromoalkynes affording gem-difluorinated alkynes. The cross-coupling proceeds in the presence of catalytic amounts of copper iodide in dimethylformamide under ligand-free c...
| Main Authors: | , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Beilstein-Institut
2015
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660974/ |