Evaluation of chromosome aberrations induced by digoxin in Chinese hamster ovary cells

Digoxin is a cardiac glycoside that has been reported to inhibit growth of multiple tumor cell types in vitro. The present study was assessing the cytogenetic effects of this drug on Chinese Hamster Ovary (CHO) cells. All experiments were performed in triplicate. The IC50 was 22.5 ± 0.8 µg/ml. To in...

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Bibliographic Details
Main Authors: Sedigh-Ardekani, Mozhgan, Saadat, Iraj, Saadat, Mostafa
Format: Online
Language:English
Published: Leibniz Research Centre for Working Environment and Human Factors 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659336/