Shearing of the CENP-A dimerization interface mediates plasticity in the octameric centromeric nucleosome

The centromeric nucleosome is a key epigenetic determinant of centromere identity and function. Consequently, deciphering how CENP-A containing nucleosomes contribute structurally to centromere function is a fundamental question in chromosome biology. Here, we performed microsecond timescale all-ato...

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Bibliographic Details
Main Authors: Winogradoff, David, Zhao, Haiqing, Dalal, Yamini, Papoian, Garegin A.
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658507/