The Default Mode Network is Disrupted in Parkinson's Disease with Visual Hallucinations

Background: Visual hallucinations (VH) are one of the most striking nonmotor symptoms in Parkinson's disease (PD), and predict dementia and mortality. Aberrant default mode network (DMN) is associated with other psychoses. Here, we tested the hypothesis that DMN dysfunction contributes to VH in...

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Main Authors:	Yao, Nailin, Shek-Kwan Chang, Richard, Cheung, Charlton, Pang, Shirley, Lau, Kui Kai, Suckling, John, Rowe, James B, Yu, Kevin, Ka-Fung Mak, Henry, Chua, Siew-Eng, Ho, Shu Leong, McAlonan, Grainne M
Format:	Online
Language:	English
Published:	Blackwell Publishing Ltd 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657500/

id	pubmed-4657500
recordtype	oai_dc
spelling	pubmed-46575002015-12-02 The Default Mode Network is Disrupted in Parkinson's Disease with Visual Hallucinations Yao, Nailin Shek-Kwan Chang, Richard Cheung, Charlton Pang, Shirley Lau, Kui Kai Suckling, John Rowe, James B Yu, Kevin Ka-Fung Mak, Henry Chua, Siew-Eng Ho, Shu Leong McAlonan, Grainne M Research Articles Background: Visual hallucinations (VH) are one of the most striking nonmotor symptoms in Parkinson's disease (PD), and predict dementia and mortality. Aberrant default mode network (DMN) is associated with other psychoses. Here, we tested the hypothesis that DMN dysfunction contributes to VH in PD. Methods: Resting state functional data was acquired from individuals with PD with VH (PDVH) and without VH (PDnonVH), matched for levodopa drug equivalent dose, and a healthy control group (HC). Independent component analysis was used to investigate group differences in functional connectivity within the DMN. In addition, we investigated whether the functional changes associated with hallucinations were accompanied by differences in cortical thickness. Results: There were no group differences in cortical thickness but functional coactivation within components of the DMN was significantly lower in both PDVH and PDnonVH groups compared to HC. Functional coactivation within the DMN was found to be greater in PDVH group relative to PDnonVH group. Conclusion: Our study demonstrates, for the first time that, within a functionally abnormal DMN in PD, relatively higher “connectivity” is associated with VH. We postulate that aberrant connectivity in a large scale network affects sensory information processing and perception, and contributes to “positive” symptom generation in PD. Hum Brain Mapp 35:5658–5666, 2014. © 2014 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. Blackwell Publishing Ltd 2014-11 2014-07-01 /pmc/articles/PMC4657500/ /pubmed/24985056 http://dx.doi.org/10.1002/hbm.22577 Text en Copyright © 2014 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Yao, Nailin Shek-Kwan Chang, Richard Cheung, Charlton Pang, Shirley Lau, Kui Kai Suckling, John Rowe, James B Yu, Kevin Ka-Fung Mak, Henry Chua, Siew-Eng Ho, Shu Leong McAlonan, Grainne M
spellingShingle	Yao, Nailin Shek-Kwan Chang, Richard Cheung, Charlton Pang, Shirley Lau, Kui Kai Suckling, John Rowe, James B Yu, Kevin Ka-Fung Mak, Henry Chua, Siew-Eng Ho, Shu Leong McAlonan, Grainne M The Default Mode Network is Disrupted in Parkinson's Disease with Visual Hallucinations
author_facet	Yao, Nailin Shek-Kwan Chang, Richard Cheung, Charlton Pang, Shirley Lau, Kui Kai Suckling, John Rowe, James B Yu, Kevin Ka-Fung Mak, Henry Chua, Siew-Eng Ho, Shu Leong McAlonan, Grainne M
author_sort	Yao, Nailin
title	The Default Mode Network is Disrupted in Parkinson's Disease with Visual Hallucinations
title_short	The Default Mode Network is Disrupted in Parkinson's Disease with Visual Hallucinations
title_full	The Default Mode Network is Disrupted in Parkinson's Disease with Visual Hallucinations
title_fullStr	The Default Mode Network is Disrupted in Parkinson's Disease with Visual Hallucinations
title_full_unstemmed	The Default Mode Network is Disrupted in Parkinson's Disease with Visual Hallucinations
title_sort	default mode network is disrupted in parkinson's disease with visual hallucinations
description	Background: Visual hallucinations (VH) are one of the most striking nonmotor symptoms in Parkinson's disease (PD), and predict dementia and mortality. Aberrant default mode network (DMN) is associated with other psychoses. Here, we tested the hypothesis that DMN dysfunction contributes to VH in PD. Methods: Resting state functional data was acquired from individuals with PD with VH (PDVH) and without VH (PDnonVH), matched for levodopa drug equivalent dose, and a healthy control group (HC). Independent component analysis was used to investigate group differences in functional connectivity within the DMN. In addition, we investigated whether the functional changes associated with hallucinations were accompanied by differences in cortical thickness. Results: There were no group differences in cortical thickness but functional coactivation within components of the DMN was significantly lower in both PDVH and PDnonVH groups compared to HC. Functional coactivation within the DMN was found to be greater in PDVH group relative to PDnonVH group. Conclusion: Our study demonstrates, for the first time that, within a functionally abnormal DMN in PD, relatively higher “connectivity” is associated with VH. We postulate that aberrant connectivity in a large scale network affects sensory information processing and perception, and contributes to “positive” symptom generation in PD. Hum Brain Mapp 35:5658–5666, 2014. © 2014 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
publisher	Blackwell Publishing Ltd
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657500/
_version_	1613505306404323328

The Default Mode Network is Disrupted in Parkinson's Disease with Visual Hallucinations

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