Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα

Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα

Both GPIbα and PAR4 are required for thrombin-induced ROS formation, suggesting a novel functional cooperation between GPIbα and PAR4. (A) Thrombin binds GPIbα, via the sulphated tyrosine sequence, and cleaves PAR4, activating the signalling molecules FAK and NOX1 and generating ROS. B. Nk protease...

Full description

Bibliographic Details
Main Authors: Carrim, Naadiya, Arthur, Jane F., Hamilton, Justin R., Gardiner, Elizabeth E., Andrews, Robert K., Moran, Niamh, Berndt, Michael C., Metharom, Pat
Format: Online
Language:English
Published: Elsevier 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656914/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656914/

Similar Items