Changes in white matter microstructure in the developing brain—A longitudinal diffusion tensor imaging study of children from 4 to 11 years of age

Changes in white matter microstructure in the developing brain—A longitudinal diffusion tensor imaging study of children from 4 to 11 years of age

The purpose of the present study was to detail the childhood developmental course of different white matter (WM) characteristics. In a longitudinal diffusion tensor imaging (DTI) study of 159 healthy children between 4 and 11 years scanned twice, we used tract-based spatial statistics as well as del...

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Main Authors: Krogsrud, Stine K., Fjell, Anders M., Tamnes, Christian K., Grydeland, Håkon, Mork, Lia, Due-Tønnessen, Paulina, Bjørnerud, Atle, Sampaio-Baptista, Cassandra, Andersson, Jesper, Johansen-Berg, Heidi, Walhovd, Kristine B.
Format: Online
Language:English
Published: Academic Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655940/
id pubmed-4655940
recordtype oai_dc
spelling pubmed-46559402016-01-01 Changes in white matter microstructure in the developing brain—A longitudinal diffusion tensor imaging study of children from 4 to 11 years of age Krogsrud, Stine K. Fjell, Anders M. Tamnes, Christian K. Grydeland, Håkon Mork, Lia Due-Tønnessen, Paulina Bjørnerud, Atle Sampaio-Baptista, Cassandra Andersson, Jesper Johansen-Berg, Heidi Walhovd, Kristine B. Article The purpose of the present study was to detail the childhood developmental course of different white matter (WM) characteristics. In a longitudinal diffusion tensor imaging (DTI) study of 159 healthy children between 4 and 11 years scanned twice, we used tract-based spatial statistics as well as delineation of 15 major WM tracts to characterize the regional pattern of change in fractional anisotropy (FA), mean (MD), radial (RD) and axial diffusivity (AD). We tested whether there were decelerations of change with increasing age globally and tract-wise, and also illustrated change along medial-to-lateral, posterior-to-anterior and inferior-to-superior gradients. We found a significant linear increase in global FA, and decrease in MD and RD over time. For mean AD, a weak decrease was observed. The developmental changes in specific WM tracts showed regional differences. Eight WM tracts showed non-linear development patterns for one or several DTI metrics, with a deceleration in change with age. Sex did not affect change in any DTI metric. Overall, greater rate of change was found in the left hemisphere. Spatially, there was a posterior-to-anterior gradient of change with greater change in frontal regions for all metrics. The current study provides a comprehensive characterization of the regional patters of change in WM microstructure across pre-adolescence childhood. Academic Press 2016-01-01 /pmc/articles/PMC4655940/ /pubmed/26375208 http://dx.doi.org/10.1016/j.neuroimage.2015.09.017 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Krogsrud, Stine K.
Fjell, Anders M.
Tamnes, Christian K.
Grydeland, Håkon
Mork, Lia
Due-Tønnessen, Paulina
Bjørnerud, Atle
Sampaio-Baptista, Cassandra
Andersson, Jesper
Johansen-Berg, Heidi
Walhovd, Kristine B.
spellingShingle Krogsrud, Stine K.
Fjell, Anders M.
Tamnes, Christian K.
Grydeland, Håkon
Mork, Lia
Due-Tønnessen, Paulina
Bjørnerud, Atle
Sampaio-Baptista, Cassandra
Andersson, Jesper
Johansen-Berg, Heidi
Walhovd, Kristine B.
Changes in white matter microstructure in the developing brain—A longitudinal diffusion tensor imaging study of children from 4 to 11 years of age
author_facet Krogsrud, Stine K.
Fjell, Anders M.
Tamnes, Christian K.
Grydeland, Håkon
Mork, Lia
Due-Tønnessen, Paulina
Bjørnerud, Atle
Sampaio-Baptista, Cassandra
Andersson, Jesper
Johansen-Berg, Heidi
Walhovd, Kristine B.
author_sort Krogsrud, Stine K.
title Changes in white matter microstructure in the developing brain—A longitudinal diffusion tensor imaging study of children from 4 to 11 years of age
title_short Changes in white matter microstructure in the developing brain—A longitudinal diffusion tensor imaging study of children from 4 to 11 years of age
title_full Changes in white matter microstructure in the developing brain—A longitudinal diffusion tensor imaging study of children from 4 to 11 years of age
title_fullStr Changes in white matter microstructure in the developing brain—A longitudinal diffusion tensor imaging study of children from 4 to 11 years of age
title_full_unstemmed Changes in white matter microstructure in the developing brain—A longitudinal diffusion tensor imaging study of children from 4 to 11 years of age
title_sort changes in white matter microstructure in the developing brain—a longitudinal diffusion tensor imaging study of children from 4 to 11 years of age
description The purpose of the present study was to detail the childhood developmental course of different white matter (WM) characteristics. In a longitudinal diffusion tensor imaging (DTI) study of 159 healthy children between 4 and 11 years scanned twice, we used tract-based spatial statistics as well as delineation of 15 major WM tracts to characterize the regional pattern of change in fractional anisotropy (FA), mean (MD), radial (RD) and axial diffusivity (AD). We tested whether there were decelerations of change with increasing age globally and tract-wise, and also illustrated change along medial-to-lateral, posterior-to-anterior and inferior-to-superior gradients. We found a significant linear increase in global FA, and decrease in MD and RD over time. For mean AD, a weak decrease was observed. The developmental changes in specific WM tracts showed regional differences. Eight WM tracts showed non-linear development patterns for one or several DTI metrics, with a deceleration in change with age. Sex did not affect change in any DTI metric. Overall, greater rate of change was found in the left hemisphere. Spatially, there was a posterior-to-anterior gradient of change with greater change in frontal regions for all metrics. The current study provides a comprehensive characterization of the regional patters of change in WM microstructure across pre-adolescence childhood.
publisher Academic Press
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655940/
_version_ 1613504907369775104

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