DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease

Cellular senescence has been associated with the structural and functional decline observed during physiological lung aging and in chronic obstructive pulmonary disease (COPD). Airway epithelial cells are the first line of defense in the lungs and are important to COPD pathogenesis. However, the mec...

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Bibliographic Details
Main Authors: Birch, Jodie, Anderson, Rhys K., Correia-Melo, Clara, Jurk, Diana, Hewitt, Graeme, Marques, Francisco Madeira, Green, Nicola J., Moisey, Elizabeth, Birrell, Mark A., Belvisi, Maria G., Black, Fiona, Taylor, John J., Fisher, Andrew J., De Soyza, Anthony, Passos, João F.
Format: Online
Language:English
Published: American Physiological Society 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652155/