Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum
During our on-going screening program designed to isolate natural compounds from marine environments, we isolated isoketochabrolic acid (IKCA) from Sargassum micracanthum, an important brown algae distributed in Jeju Island, Korea. Furthermore, we evaluated the inhibitory effects of IKCA on nitric o...
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Leibniz Research Centre for Working Environment and Human Factors
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650962/ |
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pubmed-46509622015-11-23 Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum Ham, Young Min Yoon, Weon-Jong Lee, Wook Jae Kim, Sang-Cheol Baik, Jong Seok Kim, Jin Hwa Lee, Geun Soo Lee, Nam Ho Hyun, Chang-Gu Original Article During our on-going screening program designed to isolate natural compounds from marine environments, we isolated isoketochabrolic acid (IKCA) from Sargassum micracanthum, an important brown algae distributed in Jeju Island, Korea. Furthermore, we evaluated the inhibitory effects of IKCA on nitric oxide (NO) production in lipopolysaccharide (LPS)-triggered macrophages. IKCA strongly inhibited NO production, with an IC50 value of 58.31 μM. Subsequent studies demonstrated that IKCA potently and concentration-dependently reduced prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6 cytokine production. In conclusion, to the best of our knowledge, this is the first study to show that IKCA isolated from S. micracanthum has a potent anti-inflammatory activity. Therefore, IKCA might be useful as an anti-inflammatory health supplement or functional cosmetics. Leibniz Research Centre for Working Environment and Human Factors 2015-10-15 /pmc/articles/PMC4650962/ /pubmed/26600756 http://dx.doi.org/10.17179/excli2015-555 Text en Copyright © 2015 Ham et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Ham, Young Min Yoon, Weon-Jong Lee, Wook Jae Kim, Sang-Cheol Baik, Jong Seok Kim, Jin Hwa Lee, Geun Soo Lee, Nam Ho Hyun, Chang-Gu |
| spellingShingle |
Ham, Young Min Yoon, Weon-Jong Lee, Wook Jae Kim, Sang-Cheol Baik, Jong Seok Kim, Jin Hwa Lee, Geun Soo Lee, Nam Ho Hyun, Chang-Gu Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum |
| author_facet |
Ham, Young Min Yoon, Weon-Jong Lee, Wook Jae Kim, Sang-Cheol Baik, Jong Seok Kim, Jin Hwa Lee, Geun Soo Lee, Nam Ho Hyun, Chang-Gu |
| author_sort |
Ham, Young Min |
| title |
Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum |
| title_short |
Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum |
| title_full |
Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum |
| title_fullStr |
Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum |
| title_full_unstemmed |
Anti-inflammatory effects of isoketocharbroic acid from brown alga, Sargassum micracanthum |
| title_sort |
anti-inflammatory effects of isoketocharbroic acid from brown alga, sargassum micracanthum |
| description |
During our on-going screening program designed to isolate natural compounds from marine environments, we isolated isoketochabrolic acid (IKCA) from Sargassum micracanthum, an important brown algae distributed in Jeju Island, Korea. Furthermore, we evaluated the inhibitory effects of IKCA on nitric oxide (NO) production in lipopolysaccharide (LPS)-triggered macrophages. IKCA strongly inhibited NO production, with an IC50 value of 58.31 μM. Subsequent studies demonstrated that IKCA potently and concentration-dependently reduced prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6 cytokine production. In conclusion, to the best of our knowledge, this is the first study to show that IKCA isolated from S. micracanthum has a potent anti-inflammatory activity. Therefore, IKCA might be useful as an anti-inflammatory health supplement or functional cosmetics. |
| publisher |
Leibniz Research Centre for Working Environment and Human Factors |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650962/ |
| _version_ |
1613503315544375296 |