Generic amyloidogenicity of mammalian prion proteins from species susceptible and resistant to prions

Prion diseases are lethal, infectious diseases associated with prion protein (PrP) misfolding. A large number of mammals are susceptible to both sporadic and acquired prion diseases. Although PrP is highly conserved and ubiquitously expressed in all mammals, not all species exhibit prion disease. By...

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Bibliographic Details
Main Authors: Nyström, Sofie, Hammarström, Per
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650755/