G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition

G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition

In vertebrates, embryonic hematopoietic stem and progenitor cells (HSPCs) are derived from a subset of endothelial cells, the hemogenic endothelium (HE), through the endothelial-to-hematopoietic transition (EHT). Notch signaling is essential for HSPC development during embryogenesis across vertebrat...

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Bibliographic Details
Main Authors: Zhang, Panpan, He, Qiuping, Chen, Dongbo, Liu, Weixiao, Wang, Lu, Zhang, Chunxia, Ma, Dongyuan, Li, Wei, Liu, Bing, Liu, Feng
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650626/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650626/

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