Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients

Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients

Despite advances in DNA methylome analyses of cells and tissues, current techniques for genome-scale profiling of DNA methylation in circulating cell-free DNA (ccfDNA) remain limited. Here we describe a methylated CpG tandems amplification and sequencing (MCTA-Seq) method that can detect thousands o...

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Bibliographic Details
Main Authors: Wen, Lu, Li, Jingyi, Guo, Huahu, Liu, Xiaomeng, Zheng, Shengmin, Zhang, Dafang, Zhu, Weihua, Qu, Jianhui, Guo, Limin, Du, Dexiao, Jin, Xiao, Zhang, Yuhao, Gao, Yun, Shen, Jie, Ge, Hao, Tang, Fuchou, Huang, Yanyi, Peng, Jirun
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650428/

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